Syracuse, N.Y. — Upstate Medical University is seeking patients with moderate to severe Alzheimer’s disease to participate in a new clinical trial to test how a well-established blood pressure medication may help patients with disruptive behavior.
The joint study is called PEACE-AD, which stands for Prazosin for Disruptive Agitation in Alzheimer’s Disease. Prazosin has been used for several decades to treat high blood pressure, but may be able to help Alzheimer’s patients who have disruptive behavior due to the disease.
Upstate’s Nappi Longevity Institute is participating in the study, which is being coordinated by the Alzheimer’s Disease Cooperative Study, a national academic research organization that specializes in clinical trials related to Alzheimer’s.
Disruptive agitation is a common symptom of Alzheimer’s. The behavior can include yelling, aggression, pacing, screaming and not sleeping, according to Dr. Sharon Brangman, Upstate’s chair of geriatrics. These behaviors are problematic and interfere with essential care, disrupt living environments and can be difficult and stressful for caregivers.
The nationwide clinical trial is looking to enroll 186 people with five to 10 coming from Upstate. The study will take 16 weeks and involves 13 visits, most of which can be done remotely. Participants must be living at home with a full-time caregiver and have been experiencing disruptive behaviors for four weeks. Participation will involve taking a daily medication, monitoring blood pressure with a provided device and answering a series of questions about behavior.
To volunteer for the Peace AD study or for more information, please visit this website or contact Upstate Geriatrics Clinical Research at 315-464-3285 or GeriResearch@upstate.edu.
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April 27, 2021 at 12:15AM
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